Sequence Similarities and Evolutionary Relationships of Influenza Virus A Hemagglutinins
Identifieur interne : 001766 ( Main/Exploration ); précédent : 001765; suivant : 001767Sequence Similarities and Evolutionary Relationships of Influenza Virus A Hemagglutinins
Auteurs : Andrea Ková Ová [Slovaquie] ; Gabriel Ruttkay-Nedeck [Slovaquie] ; Ivan Karol Haverlík [Slovaquie] ; S Tefan Janec Ek [Slovaquie]Source :
- Virus Genes [ 0920-8569 ] ; 2002-01-01.
English descriptors
Abstract
Abstract: This study brings the analysis of amino acid sequences of hemagglutinin (HA) from the influenza virus A that can infect a wide variety of birds and mammals. 191 sequences belonging to all known 15 HA subtypes were compared. The emphasis was given on functional sites (receptor-binding cavity with its right and left edges) and degree of their conservation in each subtype. Three evolutionary trees of 15 avian HA representatives were constructed: one tree based on the alignment of the entire HA sequences and two trees based on the alignment of HA1 and HA2 chains, respectively. The results have shown that, despite low degree of sequence similarity among the 191 sequences of HA1 subunit, the active site is well conserved, and that there are only marginal differences in the clustering of the individual HA subtypes between the two subunit trees. In this respect, the subtype H9 seems to be the most fluctuating example. The proposals of the probable avian HAs that could be the closest relatives to human (mammalian) HAs were also provided for several HA subtypes.
Url:
DOI: 10.1023/A:1014038120979
Affiliations:
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similarities</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This study brings the analysis of amino acid sequences of hemagglutinin (HA) from the influenza virus A that can infect a wide variety of birds and mammals. 191 sequences belonging to all known 15 HA subtypes were compared. The emphasis was given on functional sites (receptor-binding cavity with its right and left edges) and degree of their conservation in each subtype. Three evolutionary trees of 15 avian HA representatives were constructed: one tree based on the alignment of the entire HA sequences and two trees based on the alignment of HA1 and HA2 chains, respectively. The results have shown that, despite low degree of sequence similarity among the 191 sequences of HA1 subunit, the active site is well conserved, and that there are only marginal differences in the clustering of the individual HA subtypes between the two subunit trees. In this respect, the subtype H9 seems to be the most fluctuating example. The proposals of the probable avian HAs that could be the closest relatives to human (mammalian) HAs were also provided for several HA subtypes.</div></front></TEI><affiliations><list><country><li>Slovaquie</li></country></list><tree><country name="Slovaquie"><noRegion><name sortKey="Kova Ova, Andrea" sort="Kova Ova, Andrea" uniqKey="Kova Ova A" first="Andrea" last="Ková Ová">Andrea Ková Ová</name></noRegion><name sortKey="Haverlik, Ivan Karol" sort="Haverlik, Ivan Karol" uniqKey="Haverlik I" first="Ivan Karol" last="Haverlík">Ivan Karol Haverlík</name><name sortKey="Janec Ek, S Tefan" sort="Janec Ek, S Tefan" uniqKey="Janec Ek S" first="S Tefan" last="Janec Ek">S Tefan Janec Ek</name><name sortKey="Janec Ek, S Tefan" sort="Janec Ek, S Tefan" uniqKey="Janec Ek S" first="S Tefan" last="Janec Ek">S Tefan Janec Ek</name><name sortKey="Kova Ova, Andrea" sort="Kova Ova, Andrea" uniqKey="Kova Ova A" first="Andrea" last="Ková Ová">Andrea Ková Ová</name><name sortKey="Ruttkay Nedeck, Gabriel" sort="Ruttkay Nedeck, Gabriel" uniqKey="Ruttkay Nedeck G" first="Gabriel" last="Ruttkay-Nedeck">Gabriel Ruttkay-Nedeck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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